Several times i have people asking which ui I'm using in Everquest 2. I have used Profit UI for a long time and I'm really used to it by now. It boosts all the information i need, and it's rather clean for me. So my ui looks like this:
The ui tries to cover much information needed on screen, either from status of your character on bottom of the screen, to the different chat windows and every buff or debuff you get on game. Also, on the group frame, one can quick cure any deterimental effect just by clicking on the icon, making cure process much faster.
Instructions for installing it, can be found here.
Overall, it's a nice ui.